Nitric Oxide Concentration and Other Salivary Changes after Insertion of New Complete Dentures in Edentulous Subjects
Identifieur interne : 002D99 ( Pmc/Curation ); précédent : 002D98; suivant : 002E00Nitric Oxide Concentration and Other Salivary Changes after Insertion of New Complete Dentures in Edentulous Subjects
Auteurs : Maria De Lourdes Breseghelo [Brésil] ; Lídia Andreu Guillo [Brésil] ; Túlio Eduardo Nogueira [Brésil] ; Cláudio Rodrigues Leles [Brésil]Source :
- International Journal of Dentistry [ 1687-8728 ] ; 2016.
Abstract
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DOI: 10.1155/2016/8351427
PubMed: 27034674
PubMed Central: 4789480
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Nitric Oxide Concentration and Other Salivary Changes after Insertion of New Complete Dentures in Edentulous Subjects</title><author><name sortKey="Breseghelo, Maria De Lourdes" sort="Breseghelo, Maria De Lourdes" uniqKey="Breseghelo M" first="Maria De Lourdes" last="Breseghelo">Maria De Lourdes Breseghelo</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Biochemistry and Molecular Biology, Biological Sciences Institute, Federal University of Goias, Avenida Universitária Esquina com 1a Avenida s/n, Setor Universitário, 74605-220 Goiania, GO, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, Biological Sciences Institute, Federal University of Goias, Avenida Universitária Esquina com 1a Avenida s/n, Setor Universitário, 74605-220 Goiania, GO</wicri:regionArea></affiliation></author><author><name sortKey="Guillo, Lidia Andreu" sort="Guillo, Lidia Andreu" uniqKey="Guillo L" first="Lídia Andreu" last="Guillo">Lídia Andreu Guillo</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Biochemistry and Molecular Biology, Biological Sciences Institute, Federal University of Goias, Avenida Universitária Esquina com 1a Avenida s/n, Setor Universitário, 74605-220 Goiania, GO, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, Biological Sciences Institute, Federal University of Goias, Avenida Universitária Esquina com 1a Avenida s/n, Setor Universitário, 74605-220 Goiania, GO</wicri:regionArea></affiliation></author><author><name sortKey="Nogueira, Tulio Eduardo" sort="Nogueira, Tulio Eduardo" uniqKey="Nogueira T" first="Túlio Eduardo" last="Nogueira">Túlio Eduardo Nogueira</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Oral Prevention and Rehabilitation, School of Dentistry, Federal University of Goias, Avenida Universitária Esquina com 1a Avenida s/n, Setor Universitário, 74605-220 Goiania, GO, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Oral Prevention and Rehabilitation, School of Dentistry, Federal University of Goias, Avenida Universitária Esquina com 1a Avenida s/n, Setor Universitário, 74605-220 Goiania, GO</wicri:regionArea></affiliation></author><author><name sortKey="Leles, Claudio Rodrigues" sort="Leles, Claudio Rodrigues" uniqKey="Leles C" first="Cláudio Rodrigues" last="Leles">Cláudio Rodrigues Leles</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Oral Prevention and Rehabilitation, School of Dentistry, Federal University of Goias, Avenida Universitária Esquina com 1a Avenida s/n, Setor Universitário, 74605-220 Goiania, GO, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Oral Prevention and Rehabilitation, School of Dentistry, Federal University of Goias, Avenida Universitária Esquina com 1a Avenida s/n, Setor Universitário, 74605-220 Goiania, GO</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27034674</idno><idno type="pmc">4789480</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789480</idno><idno type="RBID">PMC:4789480</idno><idno type="doi">10.1155/2016/8351427</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">002D99</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002D99</idno><idno type="wicri:Area/Pmc/Curation">002D99</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002D99</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Nitric Oxide Concentration and Other Salivary Changes after Insertion of New Complete Dentures in Edentulous Subjects</title><author><name sortKey="Breseghelo, Maria De Lourdes" sort="Breseghelo, Maria De Lourdes" uniqKey="Breseghelo M" first="Maria De Lourdes" last="Breseghelo">Maria De Lourdes Breseghelo</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Biochemistry and Molecular Biology, Biological Sciences Institute, Federal University of Goias, Avenida Universitária Esquina com 1a Avenida s/n, Setor Universitário, 74605-220 Goiania, GO, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, Biological Sciences Institute, Federal University of Goias, Avenida Universitária Esquina com 1a Avenida s/n, Setor Universitário, 74605-220 Goiania, GO</wicri:regionArea></affiliation></author><author><name sortKey="Guillo, Lidia Andreu" sort="Guillo, Lidia Andreu" uniqKey="Guillo L" first="Lídia Andreu" last="Guillo">Lídia Andreu Guillo</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Biochemistry and Molecular Biology, Biological Sciences Institute, Federal University of Goias, Avenida Universitária Esquina com 1a Avenida s/n, Setor Universitário, 74605-220 Goiania, GO, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, Biological Sciences Institute, Federal University of Goias, Avenida Universitária Esquina com 1a Avenida s/n, Setor Universitário, 74605-220 Goiania, GO</wicri:regionArea></affiliation></author><author><name sortKey="Nogueira, Tulio Eduardo" sort="Nogueira, Tulio Eduardo" uniqKey="Nogueira T" first="Túlio Eduardo" last="Nogueira">Túlio Eduardo Nogueira</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Oral Prevention and Rehabilitation, School of Dentistry, Federal University of Goias, Avenida Universitária Esquina com 1a Avenida s/n, Setor Universitário, 74605-220 Goiania, GO, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Oral Prevention and Rehabilitation, School of Dentistry, Federal University of Goias, Avenida Universitária Esquina com 1a Avenida s/n, Setor Universitário, 74605-220 Goiania, GO</wicri:regionArea></affiliation></author><author><name sortKey="Leles, Claudio Rodrigues" sort="Leles, Claudio Rodrigues" uniqKey="Leles C" first="Cláudio Rodrigues" last="Leles">Cláudio Rodrigues Leles</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Oral Prevention and Rehabilitation, School of Dentistry, Federal University of Goias, Avenida Universitária Esquina com 1a Avenida s/n, Setor Universitário, 74605-220 Goiania, GO, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Oral Prevention and Rehabilitation, School of Dentistry, Federal University of Goias, Avenida Universitária Esquina com 1a Avenida s/n, Setor Universitário, 74605-220 Goiania, GO</wicri:regionArea></affiliation></author></analytic><series><title level="j">International Journal of Dentistry</title><idno type="ISSN">1687-8728</idno><idno type="eISSN">1687-8736</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><italic>Objective</italic>. To assess changes in levels of salivary nitric oxide (NO) after insertion of new complete dentures and its association with clinical and salivary parameters.<italic> Methods</italic>. Nineteen fully edentulous subjects were included, mean age 64.4. Unstimulated whole saliva was collected before and after insertion of the dentures, at follow-up visits, and after 12 months. The concentration of the final stable NO product (nitrite) was measured by a colorimetric assay based on the Griess reaction. Clinical parameters were assessed during all clinical visits.<italic> Results</italic>. Functional adaptation to the dentures progressively improved, with no complaints at the long-term follow-up. NO concentration was not influenced by the level of functional adaptation, presence of injuries to the mucosa, salivary flow, and saliva viscosity. Pairwise comparison showed a reduction in NO concentration at the first follow-up compared to baseline values but differences were not statistically significant. Significant differences were observed in NO concentrations at the long-term follow-up when compared to the first (<italic>p</italic> = 0.024) and second (<italic>p</italic> = 0.027) visits.<italic> Conclusion</italic>. NO concentration reduced after denture insertion and returned to baseline levels in the long-term follow-up. This appears to be an autonomic response of the body and provides valuable complementary information for the management of the edentulous patient.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Carlsson, G E" uniqKey="Carlsson G">G. E. Carlsson</name></author><author><name sortKey="Omar, R" uniqKey="Omar R">R. Omar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berg, E" uniqKey="Berg E">E. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Dent</journal-id><journal-id journal-id-type="iso-abbrev">Int J Dent</journal-id><journal-id journal-id-type="publisher-id">IJD</journal-id><journal-title-group><journal-title>International Journal of Dentistry</journal-title></journal-title-group><issn pub-type="ppub">1687-8728</issn><issn pub-type="epub">1687-8736</issn><publisher><publisher-name>Hindawi Publishing Corporation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27034674</article-id><article-id pub-id-type="pmc">4789480</article-id><article-id pub-id-type="doi">10.1155/2016/8351427</article-id><article-categories><subj-group subj-group-type="heading"><subject>Clinical Study</subject></subj-group></article-categories><title-group><article-title>Nitric Oxide Concentration and Other Salivary Changes after Insertion of New Complete Dentures in Edentulous Subjects</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Breseghelo</surname><given-names>Maria de Lourdes</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Guillo</surname><given-names>Lídia Andreu</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nogueira</surname><given-names>Túlio Eduardo</given-names></name><xref ref-type="aff" rid="I2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-6812-4849</contrib-id><name><surname>Leles</surname><given-names>Cláudio Rodrigues</given-names></name><xref ref-type="aff" rid="I2"><sup>2</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib></contrib-group><aff id="I1"><sup>1</sup>Department of Biochemistry and Molecular Biology, Biological Sciences Institute, Federal University of Goias, Avenida Universitária Esquina com 1a Avenida s/n, Setor Universitário, 74605-220 Goiania, GO, Brazil</aff><aff id="I2"><sup>2</sup>Department of Oral Prevention and Rehabilitation, School of Dentistry, Federal University of Goias, Avenida Universitária Esquina com 1a Avenida s/n, Setor Universitário, 74605-220 Goiania, GO, Brazil</aff><author-notes><corresp id="cor1">*Cláudio Rodrigues Leles: <email>claudio_leles@ufg.br</email></corresp><fn fn-type="other"><p>Academic Editor: Manal Awad</p></fn></author-notes><pub-date pub-type="ppub"><year>2016</year></pub-date><pub-date pub-type="epub"><day>29</day><month>2</month><year>2016</year></pub-date><volume>2016</volume><elocation-id>8351427</elocation-id><history><date date-type="received"><day>4</day><month>11</month><year>2015</year></date><date date-type="accepted"><day>7</day><month>2</month><year>2016</year></date></history><permissions><copyright-statement>Copyright © 2016 Maria de Lourdes Breseghelo et al.</copyright-statement><copyright-year>2016</copyright-year><license xlink:href="https://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p><italic>Objective</italic>. To assess changes in levels of salivary nitric oxide (NO) after insertion of new complete dentures and its association with clinical and salivary parameters.<italic> Methods</italic>. Nineteen fully edentulous subjects were included, mean age 64.4. Unstimulated whole saliva was collected before and after insertion of the dentures, at follow-up visits, and after 12 months. The concentration of the final stable NO product (nitrite) was measured by a colorimetric assay based on the Griess reaction. Clinical parameters were assessed during all clinical visits.<italic> Results</italic>. Functional adaptation to the dentures progressively improved, with no complaints at the long-term follow-up. NO concentration was not influenced by the level of functional adaptation, presence of injuries to the mucosa, salivary flow, and saliva viscosity. Pairwise comparison showed a reduction in NO concentration at the first follow-up compared to baseline values but differences were not statistically significant. Significant differences were observed in NO concentrations at the long-term follow-up when compared to the first (<italic>p</italic> = 0.024) and second (<italic>p</italic> = 0.027) visits.<italic> Conclusion</italic>. NO concentration reduced after denture insertion and returned to baseline levels in the long-term follow-up. This appears to be an autonomic response of the body and provides valuable complementary information for the management of the edentulous patient.</p></abstract></article-meta></front><floats-group><fig id="fig1" orientation="portrait" position="float"><label>Figure 1</label><caption><p>Changes in salivary viscosity, visual flow, and pH measures before and after insertion of new dentures at follow-up appointments. Values are represented as mean and standard error (SE).</p></caption><graphic xlink:href="IJD2016-8351427.001"></graphic></fig><fig id="fig2" orientation="portrait" position="float"><label>Figure 2</label><caption><p>Levels of functional adaptation and scores of injuries to the mucosa assessed in the follow-up appointments (<italic>n</italic> = 19). Values are presented as mean and standard error (<sup><italic>∗</italic></sup><italic>p</italic> < 0.05; Wilcoxon matched-pairs signed rank test).</p></caption><graphic xlink:href="IJD2016-8351427.002"></graphic></fig><fig id="fig3" orientation="portrait" position="float"><label>Figure 3</label><caption><p>Box-whisker plot of changes in nitric oxide levels (<italic>μ</italic>M) in unstimulated whole saliva during follow-up sessions after insertion of new complete dentures (<italic>n</italic> = 19). Box limits represent 25 and 75 percentiles, the line within the box represents median, and the whiskers represent minimum and maximum values (<sup><italic>∗</italic></sup><italic>p</italic> < 0.05; Wilcoxon matched-pairs signed rank test).</p></caption><graphic xlink:href="IJD2016-8351427.003"></graphic></fig><table-wrap id="tab1" orientation="portrait" position="float"><label>Table 1</label><caption><p>Classification of clinical parameters.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1">Variable</th><th align="center" rowspan="1" colspan="1">Categories</th><th align="left" rowspan="1" colspan="1">Criteria</th></tr></thead><tbody><tr><td align="left" rowspan="3" colspan="1">Level of functional adaptation to the dentures<sup><bold>∗</bold></sup></td><td align="center" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">Report of favorable adaptation and continuous use of the dentures; absence of or minimal complaints</td></tr><tr><td align="center" rowspan="1" colspan="1">2</td><td align="left" rowspan="1" colspan="1">Report of difficult adaptation or intermittent use of the dentures; moderate to severe complaints</td></tr><tr><td align="center" rowspan="1" colspan="1">3</td><td align="left" rowspan="1" colspan="1">Report of extreme difficulties and sporadic or no use of the dentures; severe complaints</td></tr><tr><td align="center" colspan="3" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="3" colspan="1">Injuries to the supporting mucosa<sup><bold>∗</bold></sup></td><td align="center" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">Absent</td></tr><tr><td align="center" rowspan="1" colspan="1">2</td><td align="left" rowspan="1" colspan="1">1 or 2 sore spots or ulceration evidenced by visual inspection, digital pressure or tissue compression with the denture</td></tr><tr><td align="center" rowspan="1" colspan="1">3</td><td align="left" rowspan="1" colspan="1">Multiple sore spots or ulcerations evidenced by visual inspection, digital pressure, or tissue compression with the denture</td></tr><tr><td align="center" colspan="3" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="3" colspan="1">Salivary flow rating<sup><italic>∗∗</italic></sup></td><td align="center" rowspan="1" colspan="1">Low = 1</td><td align="left" rowspan="1" colspan="1">Greater than 60 seconds</td></tr><tr><td align="center" rowspan="1" colspan="1">Normal = 2</td><td align="left" rowspan="1" colspan="1">Between 30 and 60 seconds</td></tr><tr><td align="center" rowspan="1" colspan="1">High = 3</td><td align="left" rowspan="1" colspan="1">Less than 30 seconds</td></tr><tr><td align="center" colspan="3" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="3" colspan="1">Saliva viscosity<sup>§</sup></td><td align="center" rowspan="1" colspan="1">1</td><td align="left" rowspan="1" colspan="1">Watery and transparent</td></tr><tr><td align="center" rowspan="1" colspan="1">2</td><td align="left" rowspan="1" colspan="1">Thick and sticky</td></tr><tr><td align="center" rowspan="1" colspan="1">3</td><td align="left" rowspan="1" colspan="1">Sparkling</td></tr></tbody></table><table-wrap-foot><fn><p><sup><italic>∗</italic></sup>Developed by the authors.</p></fn><fn><p><sup><italic>∗∗</italic></sup>Visual inspection test, which consisted of observing, under satisfactory illumination, and the time required for formation of saliva droplets over the lower lip mucosa [<xref rid="B20" ref-type="bibr">19</xref>].</p></fn><fn><p><sup>§</sup>Based on the criteria proposed by the Saliva-Check Buffer Testing Mat. 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